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KMID : 0613820110210121698
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Journal of Life Science
2011 Volume.21 No. 12 p.1698 ~ p.1704
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Effect of Dendranthema indicum Extracts on Cell and DNA Damage Induced by Oxidative Stress
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Park Young-Mi
Kim Jee-In
Lee Chang-Ho
Lim Jae-Hwan
Seo Eul-Won
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Abstract
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In this study, we evaluated the protective effects of ethanol extracts from Dendranthema indicum on cell and DNA damages induced by oxidative stress. Antioxidant activities of D. indicum extracts are higher than scavenging activities of DPPH free radical and hydroxyl radical by 92.8% and 73.8%, respectively, and higher than ferrous iron chelating effects by 59.4%. D. indicum extracts showed a protective effect on oxidative cell damage by inhibiting lipid peroxidation by 90.3% in the control group, and inhibiting expression level of p21 protein by 79.6% for the control group. This means D. indicum extracts have a great protective effect against oxidative stress. DNA fragmentation inhibition in D. indicum extracts were 89.6% for the control group, which makes the movement of DNA tail reduced, and phosphorylation of H2AX was 20.2% of the radical experiment group. This means that D. indicum extracts effectively inhibit DNA fragmentation and H2AX phosphorylation. Taken together, we suggest that ethanol extract from D. indicum has a role as a useful chemopreventor against oxidative damage.
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KEYWORD
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Oxidative stress, hydroxyl radical, antioxidant activity, Dendranthema indicum
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